The safety of high-dose melatonin has not been evaluated Downward-Facing Dog . Very high doses above 50 mg/day might have long-term effects on testosterone Downward-Facing Dog or prolactin levels. Patients on long-term daily melatonin or Ramelteon a melatonin analogue should be monitored for possible adverse effects Bellon, 2006. 7-Keto DHEA for Post-Traumatic Stress Disorder The literature on treatment of patients with comorbid PTSD and bipolar disorder is sparse. Retrospective studies of adults with bipolar disorder find that about half have a history of severe trauma and about 35% have comorbid PTSD. Such patients tend to have more frequent and severe mood swings, a higher incidence of comorbid substance abuse, more frequent hospitalizations, and poorer response to standard treatments Garno, Goldberg, Ramirez, & Ritzler, 2005; Leverich & Post, 2006.
A small case series five women with severe chronic PTSD due to severe early abuse reported rapid and substantial improvement in dissociative symptoms, emotional numbing, avoidance, irritability, energy, mood, memory, concentration, cognitive function, libido, anxiety, and insomnia when treated with 3-acetyl-7-oxo-dehydroepiandrosterone 7-keto DHEA, a metabolite of dehydroepiandrosterone DHEA; Sageman & Brown, 2006b. These patients were symptomatic despite years of psychotherapy and pharmacotherapy.
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