The consequences of a C/T or T/T Yoga poses for quick weight loss polymorphism are an increased level of homocysteine approximately 20% and lower folate concentrations. About 40 Yoga poses for quick weight loss -50% of the population has the C/T mutation, while 10-12% has the T/T mutation. The increase in homocysteine is associated with greater risks for cardiovascular disease. In addition, SAMe production may decline.
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The reduction in SAMe and folate along with the increase in homocysteine may contribute to depression and poor response to antidepressant medication.
One particular polymorphism with a 677C to T transition in the MTHFR gene results in an alanine to valine substitution in the polypeptide chain, which is associated with a thermolabile enzyme. The MTHFR 677TT genotype is common, occurring in 12% of the Caucasian and as high as 22% of the Latino or Mediterranean population.
It has been suggested that supplementation with L-methyltetrahydrofolate would be more effective than folic acid because this would bypass the need for the final MTHFR conversion step.