The addition of SAMe resulted in a response rate of 50 Yoga poses morning % and a remission rate of 43%. Gastrointestinal symptoms and headaches were reported as side effects Yoga poses morning in these subjects taking two antidepressants together. An earlier double-blind placebo-controlled study had shown that SAMe accelerated the response to imipramine Berlanga, Ortega-Soto, Ontiveros, & Senties, 1992.
In a six-month study of 350 patients, SAMe improved antidepressant response to imipramine. SAMe augmentation was also studied in 500 patients on benzodiazepines, 60 on monoamine oxidase inhibitors MAOIs, 445 on anticonvulsants, and 18 alcoholics on antidepressants or anticonvulsants. The addition of SAMe caused no adverse reactions.
SAMe reversed or prevented liver toxicity, as indicated by elevation of gamma-glutamyl-transpeptidase, in all patients taking MAOIs, anticonvulsants, or antidepressants Torta, Zanalda, Rocca, 1988. Case 2 SAMe With an Antidepressant Barbara, a 48-year-old special education teacher, had been taking venlafaxine Effexor-XR 300 mg/day for recurring episodes of major depression.
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