It works best when taken at least 20 to 30 minutes Yoga poses legs before breakfast and lunch on an empty stomach for maximal absorption. If the patient forgets to Yoga poses legs take it before meals, it can be taken two hours after a meal when the stomach has emptied.
If taken later in the day, there may be interference with sleep. For patients whose depression includes significant symptoms of anxiety and agitation, it is often necessary to use a benzodiazepine or buspirone during the first few weeks because the stimulating effects of SAMe can exacerbate anxiety as also occurs with stimulating antidepressants such as SSRIs.
However, within two or three weeks, as the antidepressant action is established, it is usually possible to taper off anxiolytics. Case 1 SAMe for Depression Jim, a 50-year-old business consultant, was having his fourth episode of depression. Normally an outgoing, dynamic self-starter, he was feeling insecure, indecisive, and afraid. His mind was filled with worries about a business slowdown.