SAMe deficiency in HIV+ patients may contribute to depression, Yoga poses balance demyelination, and myelopathy. SAMe 800 to 1,600 mg/day can alleviate depression Yoga poses balance and improve liver function. S-adenosylmethionine Because HIV patients are often treated with medications that place a burden on liver metabolism and cause other side effects, an antidepressant such as SAMe that supports liver functions and is low in side effects should be considered. SAMe deficiency has been found in HIV-infected patients and this may contribute to the depression, demyelination, and myelopathy that sometimes occur.
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An open-label eight-week pilot study of 20 patients with HIV and major depression given SAMe 400 mg twice a day with folic acid 800 mcg/day and B12 1,000 mcg/day found significant improvement in depression by week 4 with a drop in the mean HAMD scores from 27 to 9.Many patients with HIV are former drug abusers with abnormal liver functions due to hepatitis B and C.In this study, liver functions improved with the administration of SAMe.
None of the patients had In the authors' clinical experience, R.
Rosea in combination with SAMe can alleviate the fatigue and cognitive interference associated with Interferon treatment. Rhodiola rosea Although no studies have been done in AIDS patients, the authors find that R.rosea can help to relieve fatigue, depression, and anxiety in persons living with AIDS with minimal side effects.
AIDs patients with hepatitis C may be treated with Interferon. The debilitating fatigue and cognitive interference caused by Interferon often responds to R.rosea in combination with SAMe.
Acetyl-L-Carnitine Fatigue and antiretroviral toxic neuropathy are common severe problems in HIV patients. Different forms of carnitine have been helpful in CFS see CFS/FMS section above.