In the brain tissues of rats given 10 mg/kg Yoga Pose Dedicated to the Sage Koundinya II /day subcutaneous SAMe, free radical production decreased by about 50%, glutathione increased 50%, Yoga Pose Dedicated to the Sage Koundinya II and both glutathione peroxidase and transferase increased nearly 100% De La Cruz, Pavia, Gonzales-Correa, Ortiz, Sanchez de la Cuesta et al. Glutathione is one of the most important antioxidants, particularly in protection of nerve cell membranes.
Forty-one patients were enrolled in a DBRPC pilot study within 24 hours of ischemia or hemorrhagic stroke. Subjects were given either SAMe 2,400 mg/day IV, SAMe 3,200 mg/day IV, or placebo for 14 days.
SAMe significantly improved survival and was well tolerated Monaco, Pastore, Rizzo, et al.
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A less rigorous single-blind study of 40 elderly subjects with mild to moderate organic brain syndromes given SAMe for two months found improvement in 13 of 19 items on the Sandoz Clinical Assessment Geriatric Scale. Scales of energy, drive, confusion, and self-care indicated improvements of 2540% Fontanari, DiPalma, Giorgetti et al. 1994.