Evidence suggests that it improves brain mitochondrial function by reducing production Upward Abdominal Lock of free radicals. In a model of rat traumatic brain injury, L-deprenyl improved Upward Abdominal Lock cognitive function and neuroplasticity, particularly in the hippocampus Zhu, Hamm, Reeves, Povlishock, & Phillips, 2000. L-deprenyl was discovered by Joseph Knoll, who described a mechanism of action at a receptor site for an endogenous enhancer, which selectively improved impulse propagation-mediated release of catecholamines and serotonin. Enhancer effects on catecholamine and serotonin systems are strongest in the hippocampus.
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In response to stimulation of this receptor, glial cells and astrocytes secrete greater amounts of nerve growth factors. Higher activity levels in enhancer-sensitive neurons are associated with delay in age-related neurodegenerative changes and significantly increase longevity in six different animal species. L-deprenyl may slow the progression of Parkinson's and Alzheimer's diseases Knoll, 2000, 2003.
Several human studies show slight improvements in cognitive function in early Alzheimer's disease Mangoni, Grassi, Frattola-Piolti, Bassi et al.