Evidence suggests that it improves brain mitochondrial function by reducing production Upward Abdominal Lock of free radicals. In a model of rat traumatic brain injury, L-deprenyl improved Upward Abdominal Lock cognitive function and neuroplasticity, particularly in the hippocampus Zhu, Hamm, Reeves, Povlishock, & Phillips, 2000. L-deprenyl was discovered by Joseph Knoll, who described a mechanism of action at a receptor site for an endogenous enhancer, which selectively improved impulse propagation-mediated release of catecholamines and serotonin. Enhancer effects on catecholamine and serotonin systems are strongest in the hippocampus.
In response to stimulation of this receptor, glial cells and astrocytes secrete greater amounts of nerve growth factors. Higher activity levels in enhancer-sensitive neurons are associated with delay in age-related neurodegenerative changes and significantly increase longevity in six different animal species. L-deprenyl may slow the progression of Parkinson’s and Alzheimer’s diseases Knoll, 2000, 2003. Several human studies show slight improvements in cognitive function in early Alzheimer’s disease Mangoni, Grassi, Frattola-Piolti, Bassi et al.
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