In rat brain injury and aging models, CDP-choline Standing Forward Bend improved memory and cognitive performance and potentiated neuroplasticity mechanisms Dixon, Ma, & Marion, 1997 Standing Forward Bend . In a six-week study of 214 patients with acute middle cerebral artery ischemic stroke, those given CDP-choline within the first 24 hours showed significantly less enlargement in lesion volume on repeat MRI 12 weeks after the stroke Mitka, 2002. A meta-analysis of controlled trials of CDP-choline by the Cochrane Stroke Review Group concluded that there is some evidence that CDP-choline has positive effects on memory and behavior in the short to medium term in cerebral disorders in the elderly. The evidence for improved global impression was stronger. It warrants more long-term studies, particularly for vascular cognitive impairment, vascular dementia, and age-related memory decline Fioravanti & Yanagi, 2005.
It may be necessary to start CDP-choline within 24 hours of stroke onset for benefits to occur Parnetti, Mignini, Tomassoni, Traini, & Amenta, 2007. CDP-choline treatment has been associated with earlier recovery of consciousness, clinical and EEG improvements, accelerated motor rehabilitation, and shortened hospital stays in studies of head-injured patients, including three DBRPC and two comparative studies Calatayud Maldonado, Calatayud Perez, & Aso Escario, 1991; Levin, 1991; Lozano, 1991. According to toxicity studies, CDP-choline is quite safe and causes virtually no side effects.
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