Specific brain functions have been associated with certain vitamins: B1 Plank Yoga Pose, B2 riboflavin, B3 niacin, and B9 folate for abstract thinking; vitamin C for Plank Yoga Posevisuospatial performance; B6, B12, A, and E for visuospatial memory Bourre, 2006. A three-year cross-sectional prospective study of 4,740 elderly subjects found that a combination of vitamin C 500 mg/day plus E 400 IU/day but not either alone, nor B complex reduced the prevalence and incidence of Alzheimer's Zandi et al. 2004. Other studies support this finding Sano, 2003. B Vitamins, Folate, and Homocysteine The synthesis of cellular proteins, the maintenance of cell membranes, and the production of antioxidants occur through methylation donation of methyl groups pathways that depend on B vitamins as cofactors.
Abnormalities of mood, memory, and cognitive function have been associated with B vitamin deficiencies Bottiglieri, 1996; Hassing, Wahlin, Winblad, & Backman, 1999.
The concentration of homocysteine and its cofactors, folate, B6 pyridoxine and B12, were analyzed in 812 adults mean age 61 who had no evidence of dementia or stroke. Homocysteine levels were inversely related to cognitive performance, with adjustment for age, gender, and cardiovascular disease.
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