In a two-week DBRPC crossover study of 45 men Navasana Yoga Pose with erectile dysfunction, a combination of L-arginine glutamate 6 mg/day and yohimbine Navasana Yoga Pose 6 mg/day, yohimbine 6 mg/day alone, or placebo was taken one to two hours before sexual intercourse. Men with mild-to-moderate erectile dysfunction 14 on Erectile Function Domain had significantly better response to both interventions than men with lower scores 14 compared to placebo Lebret, Herve, Gorny, Worcel, & Botto, 2002. Acetyl-L-Carnitine Acetyl-L-carnitine plus propionyl-L-carnitine ALC significantly enhanced the efficacy of sildenafil Viagra in alleviating erectile dysfunction in a DBRPC study of 96 men after bilateral nerve-sparing retropubic prostatectomy.
Compared to men given sildenafil alone or placebo, those given ALC plus sildenafil showed significantly greater improvements in erectile function, sexual intercourse satisfaction, orgasm, and general sexual well-being Cavallini, Modenini, Vitali, & Koverech, 2005. In a six-month DBRPC study, 120 men aged 60-74 were evaluated for sexual dysfunction, depressed mood, and fatigue associated with aging.
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Compared to placebo, testosterone undecanoate 160 mg/day and carnitines propionyl-L-carnitine 2 g/day plus acetyl-L-carnitine 2 g/day significantly improved erectile function score, Depression Melancholia Scale score, and fatigue. Carnitines were more effective than testosterone on erectile function score. While increasing testosterone levels with testosterone supplementation may enhance sexual function, this may also increase prostatic volume.