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No herb-related adverse events occurred in this study. HandstandValerian and Kava A DBRPC internet-based study of kava and valerian reported no significant differences Handstandbetween kava and placebo for anxiety or between valerian and placebo for sleep disturbance Jacobs, Bent, Tice, Blackwell, & Cummings, 2005. Subject selection was based on State-Trait Anxiety Inventory subtest Stai-State and on self-report of a problem going to sleep or staying asleep over the past two weeks rather than on standard diagnostic criteria. The negative results may have been due to selection of a heterogeneous population, comorbid conditions, inadequate doses of herbs, or other limitations of internet surveys. Passionflower Passionflower Passiflora incarnata has been approved by the Komission E, a government agency that closely regulates the quality of herbal supplements in Germany, for treatment of nervous restlessness. Passionflower contains a dihydroflavone, chrysin, which binds to benzodiazepine receptors.

In a DBRPC comparison trial, 36 patients with DSM-IV generalized anxiety disorder Hamilton anxiety scale 14 were given Passiflora extract 45 drops per day plus a placebo tablet, or oxazepam a benzodiazepine 30 mg/day plus placebo drops for four weeks. Although the oxazepam effect was more rapid, Passiflora was as effective in reducing anxiety and caused less impairment in job performance Akhondzadeh, Naghavi, Vazarian, Shayeganpour, Rashidi et al.

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